Ana

Ana is a main antagonist of Rise of the Tomb Raider. She first appears in the game when Lara is in her apartment and thinks Ana is an intruder.

She was Lord Croft’s former lover, but is still friendly with Lara, and worries that she’s headed down the same self-destructive path that had led to Richard Croft's death. Ana admits that she loved Richard, and would have married him if he had asked.

It is eventually revealed that she is a member of Trinity and also Konstantin's sister, and is working with him to recover the Divine Source, which is an artifact which is purported to give it's holder eternal life. The same artifact that Richard was researching before his death, and the one Lara was currently tracking down.

She is searching for the artifact due to the fact that she is dying of lung cancer, although she still smokes, telling Konstantin to "allow her her small pleasures." Ana believes it is fine, because she would be cured of death and illness once they had the source. In the end, after Lara destroyed the source, Ana met her death, being shot by an unseen sniper working for Trinity.

Trivia

 * Ana is manipulative towards her brother, making him believe he was chosen by God. She also showed no remorse with making herself immortal, despite learning of Konstantin's death at the end of the game.
 * Like her brother but not as strongly, Ana is ruthless towards the Trinity sub-soldiers, not caring for their lives as they tried to find the Atlas, a map to lead them to the Divine Source.
 * Unlike Konstantin, her faith and trust towards Trinity isn't very strong. She knew that she was just an expendable tool to them and said this to her brother, foreshadowing the way she dies.
 * Temporarily, Ana is cured by the Divine Source just as she desired, only for Lara to snatch it away again in mere moments.
 * Ana is voice acted by Kay Bess, who had done much with narrating documentaries and voiced several characters in Dead Space.